Clinical Studies - Scientific Proof ( HgH Amino Acids )
Research Studies on the HgH Amino Acids Prove that the Ingredients
Used in the Advanced GHR Platinum HgH Releasers Really Work
Dr. L E Dorman, MD - Growth Hormone / Amino Acid Blend
Author of "The Methusaleh Factor"
As we age, our body stops producing an adequate supply of HGH amino acids. Out of the 191 amino acids in the Growth Hormone chain, GHR Platinum replenishes the body with the needed blend of Stacked HGH Amino Acids in the Right Ratio and Molecular Weight. This helps stimulate & restore the release of your body’s own natural Growth Hormone. Many substances stimulate the release of Growth Hormone from the pituitary gland. Amino acids ( from HGH chain ), drugs and exercise are among the provocateurs." ( Page 35 )
Amino Acid: L-ARGININE
The amino acid - ARGININE works in two significant ways in the human body:
First, it is a precursor used to make other substances. For example, it works by converting into the special compound Nitric Oxide. This substance plays a vital role in various metabolic activities. These include the regulation of the flow of blood, various cellular processes to create energy, and sending communications between the cells.
Nitric Oxide also functions as a vasodilator by dilating and relaxing blood vessels. This improves the circulation of the blood throughout the entire body. The result of this helps to lower high blood pressure. This also enables more nutrients from food and supplements, as well as oxygen in the blood - to be delivered to all the organs, muscles, tissues and cells of the body. In these ways, Arginine helps promote a healthy functioning of the heart. Consequently, this amino acid can useful in providing relief for conditions like Hypertension, diseases of the circulatory system, angina and Erectile Dysfunction ( ED ).
At the same time, Nitric Oxide also aids in the removal of waste products ( Lactate and Ammonia ) from both the Liver and the muscles, that are the by-products of metabolism. By removing those toxic substances from the body, it helps the muscles, and the whole body, to more rapidly recover from physical exercise and strenuous workouts.
Second, Arginine is also use to help the body to form proteins. It also promote a healthy functioning of the immune system. It is also used in the Digestive Process to digest glucose ( sugars ). In this capacity, it might help improve Insulin Sensitivity. There are some research studies that suggest that in this way it could helpful to provide relief for people who suffer from Diabetes Type 2.
One of the symptoms of the Aging Process is that as we grow older, our bodies often do not produce enough Arginine. Or else we simply do not produce it very effectively. Thus, it often becomes necessary for older people to increase their daily intake of Arginine by using supplements.
During the last approximately thirty years, there have been many clinical research studies and trials by scientists, to learn more about the effects of amino acids on levels of Human Growth Hormone ( HGH ). In particular, these include Arginine and Lysine. These studies repeatedly prove that boosting the circulating amounts of these two amino acids increases the production of Growth Hormone ( GH ) and release by the Pituitary Gland. These amino acids, along with certain other specific ones, are included in the Doctor-Approved formulas of the GHR Platinum Anti-Aging HgH Releaser supplements. Below we have provided some of these studies, which prove that these amino acids really work as Growth Hormone Releasers ( GHR ).
Growth Hormone Responses to Varying Doses of Oral Arginine
Scott R Collier; Darren P Casey; Jill A Kanaley
https://pubmed.ncbi.nlm.nih.gov/15809017/
This clinical study demonstrated that two different dosage amounts of Arginine ( 5 and 9 grams ) can produce a significant response in the levels of Growth Hormone.
Growth Hormone, Arginine and Exercise
Jill A Kanaley - Author
[ Department of Exercise Science, Syracuse University, Syracuse, New York ]
https://pubmed.ncbi.nlm.nih.gov/18090659/
The researcher concluded that most of the research studies involving the use of Arginine demonstrate that this amino acid by itself will elevate resting Growth Hormone levels at least 100%.
Increased Human Growth Hormone Following Oral Consumption
of an Amino Acid Supplement: Results of a Randomized,
Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects
Am J Ther - Author of the Manuscript
https://pmc.ncbi.nlm.nih.gov/articles/PMC6732240/
Here the author summarized with the following. It is well-known from numerous existing research studies, that application of some amino acids cause significantly higher levels of secretion of HGH. This has led to additional studies to confirm this. These particular amino acids include the following: Arginine, Lysine & Orthinine.
NOTE: Both Arginine and Lysine are included in the GHR Platinum HgH Amino Acids Blend.
A Study of Growth Hormone Release in Man After Oral Administration of Amino Acids
A Isidori; A Lo Monaco; M Cappa
https://pubmed.ncbi.nlm.nih.gov/6790230/
This study involved fifteen male volunteers. The researchers monitored and evaluated various factors of Growth Hormone secretion caused by amino acid stimulation. The test results demonstrated that the application of specific two amino acids, when combined together ( 1,200 mg L-Lysine and 1,200 mg L-Arginine ) stimulated a release of Pituitary Somatotropin { related to GH } and Insulin.
Acute Effect of Amino Acid Ingestion and Resistance Exercise
on Plasma Growth Hormone Concentration in Young Men
R R Suminski; R J Robertson; F L Goss; S Arslanian; et al
[ Human Performance Laboratory, University of Houston, TX ]
https://pubmed.ncbi.nlm.nih.gov/9063764/
Sixteen men participated in four separate study trials, chosen randomly.
In the first trial, they were given a placebo ( Vitamin C ) and then did a single session of resistance exercise.
In the second trial, they were given a dosage of 1,500 mg L-Arginine and 1,500 mg L-Lysine together. Immediately afterwards, they performed the same single session of resistance exercise.
In the third trial, they were given the same dosage of the amino acids, followed by NO exercise ( resting ).
In the fourth and final trial, they were given the placebo, followed by NO exercise ( resting ).
The researchers took measurements at intervals of 30, 60 and 90 minutes during the two exercise sessions ( 1 and 2 ). They compared the data results with the two resting trials ( 3 and 4 ). There were NO differences observed in the levels of Growth Hormone between the exercise trials.
Results of the Study and Conclusions
The researchers noted the following. Resistance exercise can raise Growth Hormone levels. However, ingesting the amino acids right before doing the exercises does not help, nor stimulate, any possible additional increase in GH levels that the exercising would normally produce.
However, when the same mixture of these two amino acids was administered in normal resting conditions, there was a sharp secretion (release) of Growth Hormone.
Amino Acid: L-LYSINE
The amino acid LYSINE is one of the eight ( 8 ) essential amino acids. This means that our bodies can not make them. We need to get them from proteins in foods which we eat. Otherwise, we must obtain them from supplements that contain them in forms which our bodies can readily digest and use.
Lysine is one of the vital amino acids, because it is necessary to create the other proteins in the body. It is also critical to make muscle tissues, and to synthesize hormones, enzymes and anti-bodies. It also plays a pivotal part in absorbing the Mineral Calcium, while at the same time, it helps to diminish the loss of calcium in urine. It also reduces Cholesterol levels.
Like the amino acid GLUTAMINE, it helps the body to heal and repair tissues and cells and recover from injuries and wounds. It acts as a Binding Agent, to help increase the number of new cells in an injury or wound that is healing. Together with the amino acid Glycine, it is required to form Collagen, that is used to form skin, nails, hair, and various connecting tissues in the body.
It is a precursor to L-Carnitine, which is a derivative of amino acids, and found in most cells of the body. This substance is important to enable the nervous system to function properly. Lysine is likewise a precursor for the compound L-Carathine, that is similarly required to maintain a healthy nervous system.
Carnitine carries Long-Chain Fatty Acids across the Mitochondria of cells and then consumes them to create energy for metabolism. Afterwards it then removes the toxins, created from the metabolic processes, out of the cells. Lysine is also critical for normal physical growth. So, a lack in the amount of Lysine can lead to all kinds of health issues and problems, such as dizziness, nausea, fatigue and slowed physical growth.
Three ( 3 ) of the studies above included both Arginine and Lysine. This establishes that the amino acid Lysine is also a Growth Hormone Releaser ( GHR ).
Amino Acid: L-GLUTAMINE
The amino acid GLUTAMINE is a vital amino acid that supports healthy brain function. It is needed for the creation of both RNA and DNA. It affects the secretion of Growth Hormone ( GH ) which then begins a process in the body which is known as "NeuroGenesis". This is how new neuron cells in the brain are made. It also supports the on-going maintenance and functioning of existing brain cells.
In a similar way, the levels of Growth Hormone also affect the levels of NeuroTransmitters in the brain. These are critical for many functions, processes and activities in the body. In particular, Glutamine is also a precursor for the making of the NeuroTransmitters GABA and Glutamate. These brain Neuro-Transmitters help to regulate and support various cognitive Functions, including mood, concentration and memory. GABA is also included in the formulations of the GHR Platinum products as one of the HgH Enhancers Complex.
Research studies demonstrate that small amounts of supplementation with Glutamine can stimulate an observable increase in GH levels in the body. For example, some clinical studies have shown that only 2 mg of this powerful amino acid could temporarily elevate the levels of Human Growth Hormone ( HGH ) by as much as 78%.
Glutamine is also a precursor to create the amino acid Arginine, which we explained above. We have seen from the research studies presented above, that it is clinically-proven to stimulate the pituitary gland to increase the production and secretion of Growth Hormone. Thus, when you increase your intake of Glutamine, by eating more proteins, or by taking supplements, you also enable your body to raise the levels of Arginine, as well as both of the NeuroTransmitters GABA and Glutamate.
How does Glutamine work to cause more Growth Hormone? The neuro-transmitter Glutamate plays a largo role in this process, by stimulating certain cells in the the Pituitary Gland called Somatotrophs. These are the special cells which signal the production and secretion ( release ) of your Human Growth Hormone.
Glutamine happens to be the most abundant amino acid found in the blood and in fluids of the body. It has many important functions. It is used to create proteins, produce energy, and help with detoxification and removal of waste products ( ie: Ammonia ), from metabolic activity.
Additionally, this amino acid is needed for a healthy functioning of the Gastro-Intestinal Tract ( GI Tract ). It also provides energy for white blood cells ( of the Immune System ) and for growth and maintenance of certain cells in the Intestines. There, it helps to maintain the barrier that separates the inside of the intestines and the rest of the body. In this capacity, it enables your body to maintain a healthy gut. This protects against getting what is called a "Leaky Gut". Thus, in this function, it also works to promote a healthy functioning of the Immune System.
When a person is going through times of a lot of stress, or has a sickness, illness or severe injury, their bodies can become depleted of Glutamine. In such times, the body typically needs more of this amino acid for the needed healing and recovery process. When there are injuries and wounds, the body requires it to repair damaged tissues and cells. At such times, if more Glutamine is needed than the body can make on its own, it must obtain it from elsewhere. So what happens is that the body might then break down proteins stored in muscles tissues, to release it from there.
When a person is experiencing stress that are very high, the body produces higher levels of CORTISOL. This is known as the "Stress Hormone". So is there a connection between stress and HgH levels in the body. Scientists have learned that Cortisol can block the production of Growth Hormone. Thus, when you reduce the amount of stress you have, you can also reduce the amount of Cortisol circulating in the body, which blocks the production and release of the very GH that you need and want to increase.
There is also a connection between Fat Burning in the body and GH. Growth Hormone actually helps in the process to breakdown fats, through what is called "Lipolysis". In this way, fats and other lipids are converted to Fatty Acids. There is also a similar link between the metabolism of carbohydrates and Growth Hormone. This then has a direct affect on blood sugar levels.
Thus Glutamine is involved in significant ways in the entire digestive function, in the conversion of starches, sugars and fats into workable energy for many activities of body metabolism. Therefore this vital amino acid Glutamine also has a huge affect on weight loss. So it is important to maintain sufficient levels of both Glutamine ( and ArginineE ). And since both of these amino acids participate in stimulating the production and release of your Growth Hormone, they both provide various important health benefits - physically, mentally and emotionally.
Research studies prove that high levels of Body Fat, particularly Belly Fat, block and reduce the production and secretion of Growth Hormone. Therefore, the amount of fat ( adipose tissue ) which men and women carry in their bodies, especially in their bellies, greatly affects the ability of their bodies, in a negative way, to produce of Human Growth Hormone. Thus, if a person can lose excess weight, especially belly fat, then they can help their bodies to naturally increase HGH output. And GHR Platinum products can help people to lose weight and increase your HGH levels in this way as well.
Increased Plasma Bicarbonate & Growth Hormone After Oral Glutamine Load
Welbourne, TC ( Department of Physiology, Louisiana State University College of Medicine, Shreveport, LA )
https://pubmed.ncbi.nlm.nih.gov/7733028/
This research study evaluated nine healthy participants. An oral load of Glutamine was given to each of them, in order to determine the effect on concentrations of Growth Hormone. The results of the test showed that even a very small amount of Glutamine was capable of elevating alkaline reserves as well as plasma GH levels.
AMINO ACID: GLYCINE
L-GLYCINE is the second most abundant amino acid in the body, that is used form various proteins. It is the most important of the amino acids required to create Collagen. Collagen is necessary for the formation of nails, skin, hair and various connective tissues in the body. This amino acid also aids in building muscles ( and energy in the muscles ), bones, supporting a proper functioning of the brain, including healthy sleep patterns.
Glycine is part of the building blocks of making the Tri-Peptide Glutathione ( an AntiOxidant that is found in the cells ). This substance is derived from the three ( 3 ) amino acids: Glutamic Acid, Cysteine, and Glycine.
Another of the symptoms of the Aging Process, is that as we grow older, our bodies often have a reduced ability to make this Anti-Oxidant Glutathione ( like the amino acid ARGININE ). So we most likely need to take a supplement to get enough of it.
The AntiOxidant Glutathione helps the body prevent damage and disease to organs ( especially the Liver ), tissues and cells, that Free Radicals can cause. When parts of the Liver that are damaged form Fibrous Tissues, they can become scarred. Or the Liver itself can become diseased through the accumulation of excessive Fat, which is a condition called Fatty Liver. Consumption of alcohol and various immune attacks can also cause the Liver to become damaged.
Glycine also works as a NeuroTransmitter in the brain. In this capacity, it works to support the processing of motor and sensory information, which enables movement, vision and hearing. It also works by helping to calm the central nervous system.
And as with the amino acid Glutamine, so also with Glycine. During periods of excessive of stress, sickness or injury, our bodies need more of it , to help repair tissues and cells and assist in the healing of wounds. But in those times, the ability of our bodies to make this critical amino acid can often become severely affected.
And lastly, this amino acid participates in the digestive process. It helps in the process of digesting fats by regulating the release of bile acids from the Gall-Bladder into the Small Intestine. Meanwhile, it also functions as what is called a "Glucogenic Amino Acid". This means that the Liver can convert it into glucose ( sugar ).
There have been numerous research studies which show and prove the link between levels of Glycine and levels of Growth Hormone. Here are just a few of them:
Glycine Stimulated Growth Hormone Release in Man
K Kasai; H Suzuki; T Nakamura; H Shiina; S I Shimoda
https://pubmed.ncbi.nlm.nih.gov/7376793/
This study investigated the effect of using Glycine on the function of the Pituitary Gland. Three different dosages amounts ( 4, 8, or 12 grams ) were given to the healthy participants during a period from 15 to 30 minutes.
The dose of 4 or 8 grams of Glycine stimulated an observable increase in serum Growth Hormone. However, a more significant increase was measured after giving the dose of 12 grams. The test test results suggest that Glycine might might play an important role in the control of Hypothalamic - Pituitary functioning. These are the two glands responsible for the creation and release of Human Growth Hormone.
Stimulatory Effect of Glycine on Human Growth Hormone Secretion
K Kasai; M Kobayashi; S I Shimoda
https://pubmed.ncbi.nlm.nih.gov/622050/
"Glycine was administered orally to 19 non-Obese normal subjects and 12 subjects with partial gastrectomy ( a total of 31 participants ). In the normal subjects, a clear and significant increase of serum Human Growth Hormone level was observed.
The researchers concluded with this: The facts demonstrated that Glycine is one of the agents which stimulates the Pituitary Gland to release HgH.
The Effect of Glycine Administration on the Characteristicsof Physiological Systems in Human Adults: A Systematic Review
Janjira Soh; Shivaanishaa Raventhiran; Jasinda H Lee; Zi Xiang Lim; Jorming Goh; Brian K Kennedy; Andrea B Maier
https://pubmed.ncbi.nlm.nih.gov/37851316/
At the start of this review, the researchers stated that decline of biological functions in the body, during aging, leads to what is known as age-released diseases. From other research studies, they understood that the amino acid Glycine helps to increases lifespan in healthy individuals. Based on this review, they suggest that administration or Glycine might help to reduce inflammation, which is often associated
with sickness, disease and break-down of the functioning or organs and systems.
Their review summarized the available evidence about applications of Glycine on the characteristics of eleven physical systems in adults. They concluded that the nervous system responded wih the most favorable effects, including improved mental symptoms from the longer-term Glycine use - where it enhanced sleep quality in healthy people.
Reduced Plasma Glycine Concentration in Healthy and Chronically Diseased
Older Adults: a Marker of Visceral Adiposity { Fat }?
Lars Nj Deutz; Raven A Wierzchowska-McNew; Nicolaas Ep Deutz; Mariëlle Pkj Engelen
[ Center for Translational Research in Aging and Longevity,
Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX ]
https://pubmed.ncbi.nlm.nih.gov/38616018/
Prior research studies have revealed that lower concentrations of plasma Glycine are related to abdominal obesity. However, the reason for this remained unknown to the scientific community. This study investigated the connection of ( visceral ) Adiposity { condition of being FAT }, in elderly adults. It aimed to discover if such factors as age, sex, body weight, body mass index ( BMI ), existence of any chronic disease, and glucose intolerance - played a role in this condition.
They took 102 older adults, consisting of 47 men and 55 women. They assessed their body composition and Visceral Adiposity Tissue. The results revealed the following finding. There was a strong link between lower plasma Glycine levels and increased body fat mass regardless of any of the above factors.
Therefore they concluded that diminished levels of Glycine in older men and women can be considered as a marker of visceral Adiposity, independent of each of those particular markers they evaluated.
AMINO ACID: TYROSINE
The amino acid TYROSINE is derived from PHENYLALANINE, one of the eight ( 8 ) essential amino acids. So, if we lack enough Phenylalanine, we will also be deficient in Tyrosine as well. Thus, we need to eat enough proteins in our diets that contain it. Otherwise, we need to get more of it by taking supplements.
Tyrosine is used to make various proteins. For example, it is involved in the making of the various Thyroid hormones ( Thyroxin ) which helps to manage metabolism, the Adreno-Cortex hormones, Melanin ( a color pigment found in the hair, skin and iris of the eyes ), some enzymes, and also various brain neuro-transmitters.
The neurotransmitters in our brains are involved with our cognitive abilities, including the following: concentration, focus, memory, working memory, mood, cognitive flexibility ( ability to switch tasks or change thoughts ) and following instructions.
This amino acid is also a precursor for the following NeuroTransmitters / Hormones - Dopamine, Epinephrine, Norepinephrine, Adrenaline and Noradrenaline. Each of these substances can affect the release / secretion of HgH in the Pituitary Gland.
Dopamine is crucial for our mental functioning and mood. It regulates the reward and pleasure centers. This important compound is also critical for memory and motor ( movement ) skills.
Adrenaline and Noradrenaline are hormones that are used in what is known as in the "Fight-or-Flight Response" in stressful situations. They enable us to stand and fight, or flee and run - from an actual attack or perceived harm. In these various ways, the amino acid Tyrosine helps us to balance the affects of both physical and mental stress.
When we are under a burden of stress, we sometimes have difficulty thinking clearly and remembering things. Research studies have shown that Tyrosine supplementation can help support and improve cognitive abilities in such conditions. Various research studies that have been performed, have shown that Tyrosine helps to lower anxiety and stress levels, and aids us to be more mentally alert.
Similarly, Tyrosine plays a part in the synthesis of certain special substances in the brain called "Enkephalins". These provide pain-relieving effects to the body. They also transmit nerve impulses and signals, and prevent conditions such as depression.So they are vital to the healthy functioning of our brains.
Additionally, this amino acid also plays a role in the regulation of blood pressure. And like other amino acids, it is used to help decrease body fat. Earlier, we have explained that excess BODY FAT, especially BELLY FAT, inhibits and blocks the production of HgH. Lastly, this amino acid also works an AntiOxidant, helping to protect the body from damage that Free Radicals can cause to organs, tissues, muscles and cells.
There has been a lot research to learn how Tyrosine works with the Pituitary Gland to stimulate it to secrete Growth Hormone. There may be an increase in the release of our GH at particular times, particularly in periods of stress.
One research study discovered that it has a major role in promoting increased levels of HGH and IGF-1 ( Insulin Growth Factor - 1 ), especially in circumstances of high stress, or during intensive physical workouts. Scientists think that it works by activating the enzyme - called Tyrosine Kinase, which then functions as a messenger, to tell the Pituitary Gland to start various metabolic processes that are linked to the production and release of Human Growth Hormone.
Meanwhile, clinical studies have shown that Tyrosine becomes more effective at elevating HgH levels, when it is combined with two other specific amino acids. And these are Arginine and Lysine. As presented above, there is already a lot of research that clearly demonstrates the ability of these two specific amino acids to elevate Growth Hormone levels. So when Tyrosine is also added, there is an even more significant increase in the production and release of GH.
Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task
Lorenza S Colzato; Bryant J Jongkees; Roberta Sellaro; Bernhard Hommel
( Institute for Psychological Research, Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands )
https://pmc.ncbi.nlm.nih.gov/articles/PMC3863934/
Tyrosine is the precursor of precursor of Dopamine ( DA ). This study investigated how Tyrosine supplies the ability needed for cognitive control functions. They examined whether markers in updating working memory, a major cognitive control operation, could be boosted by providing Tyrosine.
The researchers discovered that there is a connection between cognitive stability ( the maintenance of task-relevant representations ) and flexibility ( the ability to adapt, update and adjust between informational states ). These are two key cognitive functions which are partly opposite each other. And both of them rely on the use of Dopamine.
Using a dosage of Tyrosine supplementation versus a placebo, they tested the effect on working memory ability of the study subjects. The results revealed for the first time that Tyrosine encourages working memory updating. As they had expected, the more difficult were the cognitive demands, the more sensitive the participants were to the effect of the Tyrosine given to them. This strengthened their belief that only mental tasks requiring significant cognitive resources benefit from increased Tyrosine levels. This might be due to the fact that more demanding cognitive control operations are probably going to use up the available cognitive resources, which would then be replenished by the additional Tyrosine.
Tyrosine Promotes Cognitive Flexibility: Evidence From Proactive vs. Reactive Control During Task Switching Performance
Laura Steenbergen; Roberta Sellaro; Bernhard Hommel; Lorenza S Colzato
( Institute for Psychological Research, Leiden University, Leiden - Netherlands )
https://pubmed.ncbi.nlm.nih.gov/25598314/
The researchers noted that Tyrosine, an amino acid found in various proteins, has been demonstrated to increase Dopamine ( DA ) levels in the brain. Moreover, other studies have provided evidence that supplementation with Tyrosine can improve various aspects of cognitive control functions, particularly in situations with high cognitive demands.
This study was of a Double-Blind, Randomized, Placebo-Controlled format that involved 22 healthy adults. They researched whether Tyrosine supports cognitive flexibility, a cognitive-control operation that is presumed to be regulated by Dopamine. They tested the effect of Tyrosine on proactive versus reactive control, during task switching performance. This is a scientific diagnosis that provides a relatively well-established marker of cognitive flexibility.
Here are the results. The Tyrosine supplement promoted improved cognitive flexibility, compared to those who received the placebo. This finding supports the basis that Tyrosine can enhance cognitive flexibility by supplying necessary cognitive resources.
Behavioral and Cognitive Effects of Tyrosine Intake in Healthy Human Adults
Adrian Hase; Sophie E Jung; Marije aan het Rot
( Department of Psychology, University of Groningen, Netherlands )
https://pubmed.ncbi.nlm.nih.gov/25797188/
The amino acid Tyrosine is the precursor to the catecholamine NeuroTransmitters Dopamine and Norepinephrine. Increasing the consumption of Tyrosine may positively improve mental functioning and capacity.
The researchers performed a systematic review to learn the effects of Tyrosine on behavior and cognitive activities. They gathered fifteen research studies to see their results. All of those studies, except for one, involved a Tyrosine loading during a single test session. In most of the studies on behavior, there noticed that there were no significant effects of Tyrosine on exercise performance.
However, in studies on cognitive control operations, measured by neuro--psychological markers, they discovered that applying a load of Tyrosine sharply counter-balances gradual declines in working memory and information processing which are caused by demanding cognitive situations.
Thus they concluded that the restorative effects of Tyrosine on cognition can be understood by its ability to overcome depleted levels of catecholamines in the brain. There is evidence that supports greater levels Tyrosine can benefit healthy individuals who are exposed to demanding cognitive situations or circumstances.
Increased Human Growth Hormone Following Oral Consumption of an
Amino Acid Supplement: Results of a Randomized, Placebo-Controlled,
Double-Blind, Crossover Study in Healthy Subjects
Charmaine S Tam; William D Johnson; Jennifer Rood; Amy L Heaton; Frank L Greenway
https://pmc.ncbi.nlm.nih.gov/articles/PMC6732240/
This study was a Randomized, Double-Blind, Placebo-Controlled Crossover Study, It involved 16 healthy participants ( 12 males and 4 females ), around 32 years old, ±14 years. Each subject was given both an amino acid supplement of Tyrosine and a placebo, after an overnight fast. Each person also each of the study evaluations. The order of treatment given was randomized. Each treatment was separated by a washout period of one-week.
This is what the researchers observed. The most noteworthy result was the percent of change in levels of Hgh baseline to 120 minutes and the area under the curve of HgH over baseline. At 120 minutes, Growth Hormone levels were elevated by 682% ( an 8-fold increase ). Additionally, a higher Area Under the Curve marker was observed for those taking the supplement compared to those receiving the placebo.
The test results demonstrated that a single dose of the oral Tyrosine was sufficient to greatly increase levels of Human Growth Hormone in healthy adult men and women.
Tyrosine Hydroxylase Neurons Regulate Growth Hormone Secretion
via Short-Loop Negative Feedback
Frederick Wasinski; João AB Pedroso; Willian O dos Santos; Isadora C Furigo; David Garcia-Galiano
https://pmc.ncbi.nlm.nih.gov/articles/PMC7252485/
In this study, the researchers observed the following. Various studies have suggested that the secretion of Human Growth Hormone is controlled by negative-feedback loops which are controlled by several GH-related hormones. Two of the most influential of these are Growth Hormone - Releasing Hormone ( GH - RH ) and Somatostatin ( SS ) neurons in the brain.
They concluded that the regulation of HGH secretion depends on the ability of these neuron cells in the brain to sense changes in the levels of Growth Hormone in the body. Their research identified a specific group of Tyrosine Hydroxylase-Expressing Neurons that is vital to the ability of the brain to self-regulate the release of GH via a negative-feedback loop.
Effect of Tyrosine Supplementation on Clinical and Healthy Populations
Under Stress or Cognitive Demands - A Review
Bryant J Jongkees; Bernhard Hommel; Simone Kühn; Lorenza S Colzato
( Institute for Psychological Research & Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands
and Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany )
https://pubmed.ncbi.nlm.nih.gov/26424423/
In this review, the researchers evaluated the available studies on cognition and behavior involving the usage of a Tyrosine dosage. Ingesting the amino acid Tyrosine may counter-act gradual decreases in neurotransmitter functions and cognitive performances caused by depletion of Dopamine and Norepinephrine ( NE ).
Their summary stated the following: Tyrosine does appear to positively improve cognitive abilities, especially in short-term situations that are stressful and / or situation that require greater cognitive resources. They concluded that Tyrosine does effectively influence cognitive / mental capabilities, but only when NeuroTransmitter functions are working properly and Dopamine and / or Norepinephrine resources are temporarily exhausted.
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